TNF-α and TNF-β Gene Polymorphism in Saudi Rheumatoid Arthritis Patients
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چکیده
منابع مشابه
TNF-α and TNF-β Gene Polymorphism in Saudi Rheumatoid Arthritis Patients
BACKGROUND Tumor necrosis factor (TNF)-α and -β are cytokines with a wide range of inflammatory, apoptotic and immunomodulatory activities. TNF-α promoter -308 G < A polymorphism has been reported to be associated with rheumatoid arthritis (RA) with inconsistent results. OBJECTIVE The aim of this study is to elucidate a possible association of TNF-α (G-308A) and TNF-β (A+252G) polymorphisms w...
متن کاملSerum Levels of TNF-α, TNF-αRI, TNF-αRII and IL-12 in Treated Rheumatoid Arthritis Patients
Background: Rheumatoid arthritis (RA) is a chronic multisystem autoimmune disease common in all races and ethnics. Cytokines and cytokines receptors play an important role in RA pathogenesis and clinical presentation. Objective: To investigate the serum levels of TNF-α, TNF-α RI, TNF-α RII and IL-12 in RA patients and healthy control group. Methods: In this study 43 patients fulfilling the revi...
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OBJECTIVES Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease. Cytokines play an important role in the pathogenesis and disease progression of OLP. Various reports have implicated cytokine gene polymorphisms in susceptibility to develop some immune mediated conditions including OLP. The purpose of this study was to investigate the association of tumor necrosis factor (TNF)-...
متن کاملserum levels of tnf-α, tnf-αri, tnf-αrii and il-12 in treated rheumatoid arthritis patients
background: rheumatoid arthritis (ra) is a chronic multisystem autoimmune disease common in all races and ethnics. cytokines and cytokines receptors play an important role in ra pathogenesis and clinical presentation. objective: to investigate the serum levels of tnf-α, tnf-α ri, tnf-α rii and il-12 in ra patients and healthy control group. methods: in this study 43 patients fulfilling the revi...
متن کاملTNF-α and IL-1 β Cytokine Gene Polymorphism in Patients with Nasal Polyposis.
Objective Nasal Polyp (NP) is a benign mass of the paranasal sinuses that protrudes into the nasal cavity. The exact underlying pathogenesis is not known. In this study we aimed to determine the genetic susceptibility of NP formation in relation to TNF-α-308 and IL-1β-511 promoter region gene polymorphisms. Methods A total of 71 patients with NP with asthma (n=21) or without asthma (n=50) wer...
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ژورنال
عنوان ژورنال: Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders
سال: 2011
ISSN: 1179-5441,1179-5441
DOI: 10.4137/cmamd.s6941